I can think of nothing nicer than to join the right hon. Gentleman in all sorts of debates. He was a first-class Deputy Chief Whip in the coalition Government. Of course, he absolutely right in what he says about abattoirs. I congratulate his son on being three cheques away from...
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I can think of nothing nicer than to join the right hon. Gentleman in all sorts of debates. He was a first-class Deputy Chief Whip in the coalition Government. Of course, he absolutely right in what he says about abattoirs. I congratulate his son on being three cheques away from...
It is a pleasure to follow the hon. Member for Selby and Ainsty (Keir Mather), although I will stay out of the minor internal argument between him and the hon. Member for Mid Bedfordshire (Alistair Strathern) about who is more rural. Although I have no technical interest to declare, I...
It is a pleasure to follow the hon. Member for Selby and Ainsty (Keir Mather), although I will stay out of the minor internal argument between him and the hon. Member for Mid Bedfordshire (Alistair Strathern) about who is more rural. Although I have no technical interest to declare, I...
It is a pleasure to follow the hon. Member for Somerton and Frome (Sarah Dyke).
It was 40 years ago, at just about this moment, that I asked a gorgeous farmer’s daughter from the Isles of Scilly if she would go out on a date with me. She said yes, and...
It is a pleasure to follow the hon. Member for Somerton and Frome (Sarah Dyke).
It was 40 years ago, at just about this moment, that I asked a gorgeous farmer’s daughter from the Isles of Scilly if she would go out on a date with me. She said yes, and...
DOI: https://doi.org/10.58248/PN716
Human pluripotent stem cells have been used to generate models of the human embryo (stem cell-based embryo models; SCBEMs). Pluripotent stem cells are unspecialised cells that posses the ability to develop into other cell types. SCBEM is an umbrella term used to refer to a range of models that vary in complexity and completeness of modelling an embryo.
Scientists propose that human SCBEMs can be used to better understand early embryo development and this knowledge could have the potential to explore factors contributing to pregnancy loss, miscarriages and to improve IVF outcomes. SCBEMs have also been proposed to be useful in drug testing and discovery.
With increasing sophistication and completeness of human SCBEMs in modelling the embryo, the focus of the current debate includes how existing legislation relates to technological progress in this area, and whether the same laws governing embryo research should apply to SCBEMs as well.
In the UK, as of February 2024, human SCBEMs are not explicitly defined or regulated by existing legislation governing embryo research.
Opportunities in introducing regulation of human SCBEMs include the requirement for an assessment of the extent to which SCBEMs resemble or differ from an embryo, clarity on restrictions surrounding their maintenance in vitro and understanding public concerns and perceptions around them.
In November 2023, the Human Fertilisation and Embryology Authority proposed reformation of the Human Fertilisation and Embryology Act 2008. The report recognised human SCBEMs as pressing scientific issues and included proposals for greater discretion to approve new developments under flexible trial mechanisms with the aim of “future proofing” scientific developments.
Key Points
- Human SCBEMs are created from pluripotent stem cells.
- Human SCBEMs could allow novel forms of investigation into embryonic processes that would not be possible or practical with human embryos.
- The terminology describing SCBEMs can vary; they have been referred to as artificial embryos, synthetic embryos, stembryos, synthetic human entities with embryo-like features (SHEEFs), embryo-like structures (ELS), embryo models and embryoids.
- Internationally, legal definitions and regulations around human SCBEMs varies from no explicit regulation to different limits on its research.
- The International Society for Stem Cell Research have created guidelines to address the international diversity of cultural, political, legal and ethical issues around the emerging technology and its application in research and treatment.
- Stakeholder suggestions towards effective oversight of SCBEMs include (i) identifying similarities and differences between SCBEMs and human embryos, (ii) an independent oversight process involving experts and lay members (iii) conducting public engagement to increase public understanding and identifying concerns surrounding the technology.
Contributors
POST is grateful to Jahnavi Bhaskaran for researching this briefing, to the Nuffield Foundation for funding her fellowship, and to all contributors and reviewers. For further information on this subject, please contact the co-author, Natasha Mutebi.
POSTnotes are based on literature reviews and interviews with a range of stakeholders and are externally peer reviewed. POST would like to thank interviewees and peer reviewers for kindly giving up their time during the preparation of this briefing, including:
Members of the POST Board*
Steve Pugh, Department of Health & Social Care (DHSC)*
Department of Science, Innovation & Technology (DSIT)
Professor David Albert Jones, Anscombe Bioethics Centre*
Professor Paula Amato, American Society for Reproductive Medicine (ASRM)
Victoria Askew, Human Fertility and Embryology Authority UK (HFEA)
Dr Zoe Bolton, Lancaster University*
Dr Chris Burns, Medicines and Healthcare products Regulatory Agency (MHRA)*
Dr Lee Carpenter, UK Stem Cell Bank (UKSCB), Medicines and Healthcare products Regulatory Agency (MHRA)*
Professor Sara Fovargue, University of Sheffield*
Professor Sarah Franklin, University of Cambridge
Dina Halai, Human Fertility and Embryology Authority UK (HFEA) *
Professor Soren Holm, University of Manchester*
Dr Hafez Ismaili M'hamdi, Maastricht University
Professor Emily Jackson, London School of Economics and Political Science (LSE)*
Professor Susan Kimber, University of Manchester
Dr Jonathan Lewis, University of Manchester*
Professor Robin Lovell-Badge, The Francis Crick Institute*
Dr Calum MacKellar, Scottish Council on Human Bioethics*
Professor Saitou Mitinori, Kyoto University
Dr Naomi Moris, The Francis Crick Institute*
Professor Megan Munsie, University of Melbourne*
Dr Laura O'Donovan, Lancaster University*
Dr Greg Pike, Society for the Protection of Unborn Children (SPUC)*
Dr Peter Rugg-Gunn, Babraham Institute*
Dr Nicolas Rivron, Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA)*
Dr Peter Ruane, University of Manchester
Sandy Starr, Progress Educational Trust (PET)*
Professor Roger Sturmey, University of Manchester*
Ranveig Svenning Berg, Nuffield Council on Bioethics*
Dr Robert Watson, Human Tissue Authority (HTA)*
Professor Stephen Wilkinson, Lancaster University*
Dr Nicola Williams, Lancaster University*
Right to Life UK
* denotes people and organisations who acted as external reviewers of the briefing.
DOI: https://doi.org/10.58248/PN716
Human pluripotent stem cells have been used to generate models of the human embryo (stem cell-based embryo models; SCBEMs). Pluripotent stem cells are unspecialised cells that posses the ability to develop
With permission, Madam Deputy Speaker, I would like to make a statement on the security of elected representatives.
This House brings together our nation. People from every part of the United Kingdom and from every background are represented here to debate, to argue, to challenge and to find the best course...
With permission, Madam Deputy Speaker, I would like to make a statement on the security of elected representatives.
This House brings together our nation. People from every part of the United Kingdom and from every background are represented here to debate, to argue, to challenge and to find the best course...
My Lords, it is always a great pleasure to follow the noble Baroness, Lady Suttie, on occasions such as this. She, like others, made reference to Lord Patrick Cormack. I want to put on record my thanks for his friendship over the years. I knew him for approximately 34 years,...
My Lords, it is always a great pleasure to follow the noble Baroness, Lady Suttie, on occasions such as this. She, like others, made reference to Lord Patrick Cormack. I want to put on record my thanks for his friendship over the years. I knew him for approximately 34 years,...
With permission, Mr Speaker, I will make a brief statement. Over the past few weeks, we have seen disgraceful attempts to intimidate this House, to undermine the democratic process and to spread fear among those who have been elected to represent our country. That is unacceptable. It must end.
To this House, I want to say clearly that the Government will defend our democracy. We are working with the police and with Parliament to ensure that disagreements are resolved in this House through debate, not outside with threats of violence. To those who seek to threaten this House, I say this: we will not be cowed; we will not be intimidated; and we will not be silenced. We will do whatever is necessary to protect those elected to represent us, to safeguard our freedoms and to protect our rights. I know I speak for colleagues across the whole House when I say we will always act in the interests of our constituents and our country.
With permission, Mr Speaker, I will make a brief statement. Over the past few weeks, we have seen disgraceful attempts to intimidate this House, to undermine the democratic process and to spread fear among those who have been elected to represent our country. That is unacceptable. It must end.
To this House, I want to say clearly that the Government will defend our democracy. We are working with the police and with Parliament to ensure that disagreements are resolved in this House through debate, not outside with threats of violence. To those who seek to threaten this House, I say this: we will not be cowed; we will not be intimidated; and we will not be silenced. We will do whatever is necessary to protect those elected to represent us, to safeguard our freedoms and to protect our rights. I know I speak for colleagues across the whole House when I say we will always act in the interests of our constituents and our country.
If he will make a statement on his departmental responsibilities.
On 20 February 2024, the Prime Minister Rishi Sunak gave a speech at the annual conference of the National Farmers’ Union. Agricultural policy is a devolved matter. This briefing provides statistics on farms in England and focuses on some of the Prime Minister’s key announcements.
On 20 February 2024, the Prime Minister Rishi Sunak gave a speech at the annual conference of the National Farmers’ Union. Agricultural policy is a devolved matter. This briefing provides statistics on farms in England and focuses on some of the Prime Minister’s key announcements.
To ask the Secretary of State for Environment, Food and Rural Affairs, how many upland farms have closed in each year since 2015 by region.
To ask the Secretary of State for Environment, Food and Rural Affairs, how many upland farms have closed in each year since 2015 by region.
Defra does not hold any data on the number of farms that have ceased farming in any particular year. We produce statistical estimates of national crop areas and livestock populations each year, but we do not track changes in individual farms. Changes in national/regional activity can be seen in our annual publications and this includes the number of agricultural holdings with significant levels of farming activity* in England. Changes in the number of holdings could be for a number of reasons, in addition to ceasing trading.
* Data only covers holdings which are registered with the Rural Payments Agency for payments or livestock purposes and have significant levels of farming activity (as recorded in responses to the Defra June Survey of Agriculture or the Cattle Tracing System). Holdings are only included if they have more than five hectares of agricultural land, one hectare of orchards, 0.5 hectares of vegetables or 0.1 hectares of protected crops, or more than 10 cows, 50 pigs, 20 sheep, 20 goats or 1,000 poultry.
Number of holdings by region are available here.
Number of holdings in the uplands (less favoured areas) are available here.
Number of holdings by farm type are available here.
Does my right hon. Friend agree that the real issue of the events of the last 24 hours is not the party political shenanigans suggested by the shadow Leader of the House, but that this House appears cowed by threats of violence and intimidation? The mother of Parliaments appears weakened...
Does my right hon. Friend agree that the real issue of the events of the last 24 hours is not the party political shenanigans suggested by the shadow Leader of the House, but that this House appears cowed by threats of violence and intimidation? The mother of Parliaments appears weakened...
My Lords, some freeholders, although not all, treat their leaseholders as a cash cow. I have two examples for the Minister. First, there was a ground rent increase—and there is no value at all to the leaseholder in a ground rent—of 113% this year, which was backdated three years, and the sum was demanded to be paid in full in four weeks. Secondly, there was a 23% increase in service charges this year. There is no accountability. Transparency there is, and challenge there can be, but nothing comes of it—and it seems that nothing in the Bill will change that. Can the Minister tell me that it will?
My Lords, some freeholders, although not all, treat their leaseholders as a cash cow. I have two examples for the Minister. First, there was a ground rent increase—and there is no value at all to the leaseholder in a ground rent—of 113% this year, which was backdated three years, and the sum was demanded to be paid in full in four weeks. Secondly, there was a 23% increase in service charges this year. There is no accountability. Transparency there is, and challenge there can be, but nothing comes of it—and it seems that nothing in the Bill will change that. Can the Minister tell me that it will?
I can. The Government have consulted on a range of options to reform existing ground rents, having legislated in 2022 to set all new ground rents at a peppercorn rate. Following the outcome of that consultation, we aim to legislate in the current Bill before Parliament. As I say, not only will we give leaseholders greater rights to transparency on what service charges are charged for, to ensure that they are reasonable, but we are changing the cost regime in the courts so they can challenge those charges where they think they are unreasonable.
To ask His Majesty's Government whether they have made representations to the government of Israel concerning the land dispute at Cows' Garden in the Armenian Quarter of Jerusalem in the Occupied Palestinian Territories; and if so, what the outcomes of those representations were.
To ask His Majesty's Government whether they have made representations to the government of Israel concerning the land dispute at Cows' Garden in the Armenian Quarter of Jerusalem in the Occupied Palestinian Territories; and if so, what the outcomes of those representations were.
British officials met Armenian Community leader Hagop Djernazian in January 2024. The UK is monitoring the situation and is clear on the need to avoid any further rise in tensions. The UK's position on the status of Jerusalem is clear and long-standing: it should be determined in a negotiated settlement between the Israelis and the Palestinians, and Jerusalem should ultimately be the shared capital of the Israeli and Palestinian states. The UK is a strong supporter of Freedom of Religion or Belief (FoRB) and an advocate for the integrity of culturally important areas to be respected. The UK continues to take a strong stance against settler violence and urges Israel to take stronger action to stop settler violence and hold the perpetrators accountable.
To ask the Minister of State, Foreign, Commonwealth and Development Office, whether he has had recent discussions with his Israeli counterpart on the (a) recent physical assault on Hagop Djernazian and (b) safety of Armenians in the Old City of Jerusalem.
To ask the Minister of State, Foreign, Commonwealth and Development Office, whether he has had recent discussions with his Israeli counterpart on the (a) recent physical assault on Hagop Djernazian and (b) safety of Armenians in the Old City of Jerusalem.
We have not held discussions with Israeli counterparts on the situation in the Cow Garden site of the Armenian Quarter in the Old City of Jerusalem. The UK is monitoring the situation and is clear on the need to avoid any further rise in tensions. British Consulate General staff in Jerusalem met members of the community on 19 January, discussed the current situation and visited the Cow's Garden site. The UK's position on the status of Jerusalem is clear and long-standing: it should be determined in a negotiated settlement between the Israelis and the Palestinians, and Jerusalem should ultimately be the shared capital of the Israeli and Palestinian states. The UK is a strong supporter of Freedom of Religion or Belief (FoRB) and an advocate for the integrity of cultural important areas to be respected. The UK continues to take a strong stance against settler violence and urges Israel to take stronger action to stop settler violence and hold the perpetrators accountable.
My Lords, 136: I shall repeat the number 136 because on Wednesday Ashley Waxman Bakshi asked a packed room of parliamentarians to keep reminding the world that there are still 136 hostages in Gaza, including Ashley’s cousin Agam Berger.
We are here today for Holocaust Memorial Day to keep the memory...
My Lords, 136: I shall repeat the number 136 because on Wednesday Ashley Waxman Bakshi asked a packed room of parliamentarians to keep reminding the world that there are still 136 hostages in Gaza, including Ashley’s cousin Agam Berger.
We are here today for Holocaust Memorial Day to keep the memory...
I congratulate my right hon. Friend the Member for Suffolk Coastal (Dr Coffey) on bringing forward this incredibly important debate. I thank my hon. Friend the Member for Ynys Môn (Virginia Crosbie) for her tireless commitment in terms of meeting her constituents and the work she did through her 10-minute...
I congratulate my right hon. Friend the Member for Suffolk Coastal (Dr Coffey) on bringing forward this incredibly important debate. I thank my hon. Friend the Member for Ynys Môn (Virginia Crosbie) for her tireless commitment in terms of meeting her constituents and the work she did through her 10-minute...
My Lords, I support my noble friend’s amendments, and I particularly emphasise the points we have heard about having people with expertise. The right reverend Prelate spoke very clearly about this.
This can also be very much affected by dialect-inflected accents which mean that it can be very hard for everyone,...
My Lords, I support my noble friend’s amendments, and I particularly emphasise the points we have heard about having people with expertise. The right reverend Prelate spoke very clearly about this.
This can also be very much affected by dialect-inflected accents which mean that it can be very hard for everyone,...
First, let me say that we on the SNP Benches are also not looking to divide the House. I thought that I might get the opportunity to pre-empt the jibe that is often made about how my party is against trade deals, but the hon. Member for Totnes (Anthony Mangnall)...
First, let me say that we on the SNP Benches are also not looking to divide the House. I thought that I might get the opportunity to pre-empt the jibe that is often made about how my party is against trade deals, but the hon. Member for Totnes (Anthony Mangnall)...
My Lords, as a new entrant farmer, I think that there is another kind of endangered species that we have missed here, and that is the farmers themselves. As I have come into farming, lots of people are just leaving it. One of the reasons for that is that we...
My Lords, as a new entrant farmer, I think that there is another kind of endangered species that we have missed here, and that is the farmers themselves. As I have come into farming, lots of people are just leaving it. One of the reasons for that is that we...
My hon. Friend, with her immense experience and perspective as Chair of the Foreign Affairs Committee, is absolutely right about the formation of the Houthis, who, if we look back at their history, are actually opportunists. Only as far back as 2015, they did not support Hamas. Now they claim...
My hon. Friend, with her immense experience and perspective as Chair of the Foreign Affairs Committee, is absolutely right about the formation of the Houthis, who, if we look back at their history, are actually opportunists. Only as far back as 2015, they did not support Hamas. Now they claim...
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